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il 6  (R&D Systems)


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    R&D Systems il 6
    Il 6, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 921 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+human+il+6/Recombinant+Human+IL-6+Protein/us12606556-555-11-15
    Average 96 stars, based on 921 article reviews
    il 6 - by Bioz Stars, 2026-09
    96/100 stars

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    Related Articles

    Control:

    Article Title: The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
    Article Snippet: To determine premature senescence, ECs between passages 4 and 5 were transfected with siRNAs (80 nM, control siRNA, #sc-37007; human REDD1, #sc-45806; mouse Redd1, #sc-45807; human IKKβ, #sc-35644; human NF-κB p65, #sc-29410; mouse NF-κB p65, #sc-29411; human Raptor, #44069; human DICER, #sc40489; Santa Cruz Biotechnology), miRNA mimics or inhibitors (80 nM, Supplementary Table ), pFLAG-REDD1 (1 μg DNA/ml) , or plasmid DNAs (1 μg/ml; human WT or DN mutant H363Y SIRT1 ; Plasmid #1791, Addgene, Watertown, MA, USA) using Lipofectamine RNAiMAX or Lipofectamine 3000 (Invitrogen). .. Cells were then treated with or without oxLDL (50 μg/ml), prepared by incubating native LDL (1.019 mg protein) with 10 μM CuSO4 for 4 h , cholesterol (100 μM, #C8667; Sigma-Aldrich, St. Louis, MO, USA), glucose (25 mM, 25 mM L -glucose used for osmotic control), recombinant human resistin (100 ng/ml, #1359-RN; R&D systems, Minneapolis, MN, USA), recombinant human leptin (10 μg/ml, #398-LP; R&D Systems), recombinant human TNF-α (10 ng/ml, #10291-TA; R&D Systems), recombinant human IL-6 (40 ng/ml, #206-IL; R&D Systems), palmitate-BSA (300 μM), or H 2 O 2 (50–150 μM) for 48 h. Palmitic acid-BSA solution (5 mM) was prepared by mixing 10 μL of palmitate solution (500 mM in ethanol, #P9767; Sigma-Aldrich) with 1 mL of BSA solution (10%, w/v in serum-free M199, #A8806; Sigma-Aldrich). .. Subsequently, the solution was filtered through a 0.22 μm pore size membrane filter (Millipore, Billerica, MA) and stored at −80 °C until use.

    Article Title: The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
    Article Snippet: To determine premature senescence, ECs between passages 4 and 5 were transfected with siRNAs (80 nM, control siRNA, #sc-37007; human REDD1, #sc-45806; mouse Redd1, #sc-45807; human IKKβ, #sc-35644; human NF-κB p65, #sc-29410; mouse NF-κB p65, #sc29411; human Raptor, #44069; human DICER, #sc40489; Santa Cruz Biotechnology), miRNA mimics or inhibitors (80 nM, Supplementary Table 1), pFLAG-REDD1 (1 μg DNA/ml), or plasmid DNAs (1 μg/ml; human WT or DN mutant H363Y SIRT1; Plasmid #1791, Addgene, Watertown, MA, USA) using Lipofectamine RNAiMAX or Lipofectamine 3000 (Invitrogen). .. Cells were then treated with or without oxLDL (50 μg/ml), prepared by incubating native LDL (1.019 mg protein) with 10 μM CuSO4 for 4 h, cholesterol (100 μM, #C8667; Sigma-Aldrich, St. Louis, MO, USA), glucose (25 mM, 25 mM L-glucose used for osmotic control), recombinant human resistin (100 ng/ml, #1359-RN; R&D systems, Minneapolis, MN, USA), recombinant human leptin (10 μg/ml, #398-LP; R&D Systems), recombinant human TNF-α (10 ng/ml, #10291-TA; R&D Systems), recombinant human IL-6 (40 ng/ml, #206-IL; R&D Systems), palmitate-BSA (300 μM), or H2O2 (50−150 μM) for 48 h. Palmitic acid-BSA solution (5 mM) was prepared by mixing 10 μL of palmitate solution (500 mM in ethanol, #P9767; Sigma-Aldrich) with 1 mL of BSA solution (10%, w/v in serum-free M199, #A8806; Sigma-Aldrich). .. Subsequently, the solution was filtered through a 0.22 μm pore size membrane filter (Millipore, Billerica, MA) and stored at −80°C until use.

    Article Title: The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
    Article Snippet: To determine premature senescence, ECs between passages 4 and 5 were transfected with siRNAs (80 nM, control siRNA, #sc-37007; human REDD1, #sc-45806; mouse Redd1, #sc-45807; human IKKβ, #sc-35644; human NF-κB p65, #sc-29410; mouse NF-κB p65, #sc- 29411; human Raptor, #44069; human DICER, #sc40489; Santa Cruz Biotechnology), miRNA mimics or inhibitors (80 nM, Supplementary Table 1), pFLAG-REDD1 (1 μg DNA/ml)19, or plasmid DNAs (1 μg/ml; human WT or DN mutant H363Y SIRT1; Plasmid #1791, Addgene, Watertown, MA, USA) using Lipofectamine RNAiMAX or Lipofectamine 3000 (Invitrogen). .. Cells were then treated with or without oxLDL (50 μg/ml), prepared by incubating native LDL (1.019 mg protein) with 10 μM CuSO4 for 4 h64, cholesterol (100 μM, #C8667; Sigma-Aldrich, St. Louis, MO, USA), glucose (25 mM, 25 mM L-glucose used for osmotic control), recombinant human resistin (100 ng/ml, #1359-RN; R&D systems, Minneapolis, MN, USA), recombinant human leptin (10 μg/ml, #398-LP; R&D Systems), recombinant human TNF-α (10 ng/ml, #10291-TA; R&D Systems), recombinant human IL-6 (40 ng/ml, #206-IL; R&D Systems), palmitate-BSA (300 μM), or H2O2 (50−150 μM) for 48 h. Palmitic acid-BSA solution (5 mM) was prepared by mixing 10 μL of palmitate solution (500 mM in ethanol, #P9767; Sigma-Aldrich) with 1 mL of BSA solution (10%, w/v in serum-free M199, #A8806; Sigma-Aldrich). ..

    Recombinant:

    Article Title: The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
    Article Snippet: To determine premature senescence, ECs between passages 4 and 5 were transfected with siRNAs (80 nM, control siRNA, #sc-37007; human REDD1, #sc-45806; mouse Redd1, #sc-45807; human IKKβ, #sc-35644; human NF-κB p65, #sc-29410; mouse NF-κB p65, #sc-29411; human Raptor, #44069; human DICER, #sc40489; Santa Cruz Biotechnology), miRNA mimics or inhibitors (80 nM, Supplementary Table ), pFLAG-REDD1 (1 μg DNA/ml) , or plasmid DNAs (1 μg/ml; human WT or DN mutant H363Y SIRT1 ; Plasmid #1791, Addgene, Watertown, MA, USA) using Lipofectamine RNAiMAX or Lipofectamine 3000 (Invitrogen). .. Cells were then treated with or without oxLDL (50 μg/ml), prepared by incubating native LDL (1.019 mg protein) with 10 μM CuSO4 for 4 h , cholesterol (100 μM, #C8667; Sigma-Aldrich, St. Louis, MO, USA), glucose (25 mM, 25 mM L -glucose used for osmotic control), recombinant human resistin (100 ng/ml, #1359-RN; R&D systems, Minneapolis, MN, USA), recombinant human leptin (10 μg/ml, #398-LP; R&D Systems), recombinant human TNF-α (10 ng/ml, #10291-TA; R&D Systems), recombinant human IL-6 (40 ng/ml, #206-IL; R&D Systems), palmitate-BSA (300 μM), or H 2 O 2 (50–150 μM) for 48 h. Palmitic acid-BSA solution (5 mM) was prepared by mixing 10 μL of palmitate solution (500 mM in ethanol, #P9767; Sigma-Aldrich) with 1 mL of BSA solution (10%, w/v in serum-free M199, #A8806; Sigma-Aldrich). .. Subsequently, the solution was filtered through a 0.22 μm pore size membrane filter (Millipore, Billerica, MA) and stored at −80 °C until use.

    Article Title: The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
    Article Snippet: To determine premature senescence, ECs between passages 4 and 5 were transfected with siRNAs (80 nM, control siRNA, #sc-37007; human REDD1, #sc-45806; mouse Redd1, #sc-45807; human IKKβ, #sc-35644; human NF-κB p65, #sc-29410; mouse NF-κB p65, #sc29411; human Raptor, #44069; human DICER, #sc40489; Santa Cruz Biotechnology), miRNA mimics or inhibitors (80 nM, Supplementary Table 1), pFLAG-REDD1 (1 μg DNA/ml), or plasmid DNAs (1 μg/ml; human WT or DN mutant H363Y SIRT1; Plasmid #1791, Addgene, Watertown, MA, USA) using Lipofectamine RNAiMAX or Lipofectamine 3000 (Invitrogen). .. Cells were then treated with or without oxLDL (50 μg/ml), prepared by incubating native LDL (1.019 mg protein) with 10 μM CuSO4 for 4 h, cholesterol (100 μM, #C8667; Sigma-Aldrich, St. Louis, MO, USA), glucose (25 mM, 25 mM L-glucose used for osmotic control), recombinant human resistin (100 ng/ml, #1359-RN; R&D systems, Minneapolis, MN, USA), recombinant human leptin (10 μg/ml, #398-LP; R&D Systems), recombinant human TNF-α (10 ng/ml, #10291-TA; R&D Systems), recombinant human IL-6 (40 ng/ml, #206-IL; R&D Systems), palmitate-BSA (300 μM), or H2O2 (50−150 μM) for 48 h. Palmitic acid-BSA solution (5 mM) was prepared by mixing 10 μL of palmitate solution (500 mM in ethanol, #P9767; Sigma-Aldrich) with 1 mL of BSA solution (10%, w/v in serum-free M199, #A8806; Sigma-Aldrich). .. Subsequently, the solution was filtered through a 0.22 μm pore size membrane filter (Millipore, Billerica, MA) and stored at −80°C until use.

    Article Title: Evaluation of anti-drug antibodies against therapeutic monoclonal antibodies and related product in Japanese patients with rheumatoid arthritis and their clinical impact.
    Article Snippet: All serum samples were filtered through a 0.22-m filter tube (Spin-X Centrifuge Tube Filters; Corning, One Riverfront Plaza, NY) before use. .. Recombinant human TNF- (FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) and recombinant human IL-6 (R&D Systems, Minneapolis, MN) were used for reporter gene assays for evaluating neutralization activity. .. Human anti-IFX antibody HCA215, human anti-ADM antibody HCA204, human anti-GLM monoclonal antibody HCA241, human-TCZ monoclonal antibody HCA254, human antiETN monoclonal antibody HCA 277 (Bio-Rad, Hercules, CA), and mouse anti-ETN monoclonal antibody SB-01-112 (Somru BioScience, PEI, Canada) were used as positive controls.

    Article Title: IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR -mutant non–small cell lung cancer
    Article Snippet: Infliximab (Mitsubishi Tanabe Pharma, Osaka, Japan) and tocilizumab (Chugai Pharmaceutical, Tokyo, Japan) were stored at − 20 °C. .. Recombinant human TNF-α (#210-TA-005, R&D Systems), recombinant human IFN-γ (#300-02, Peprotech), and recombinant human IL-6 (#206-IL, R&D Systems) were dissolved in sterile phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin and were stored at − 20 °C. .. Cells were transferred to 96-well plates (Greiner Bio-One) and subjected to transient transfection for 24 h with a small interfering RNA (siRNA) specific for IFITM3 (ID s195035, Thermo Fisher Scientific) or a negative control siRNA (ID 4390843, Thermo Fisher Scientific), each mixed with the RNAiMAX reagent (Thermo Fisher Scientific).

    Article Title: The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
    Article Snippet: To determine premature senescence, ECs between passages 4 and 5 were transfected with siRNAs (80 nM, control siRNA, #sc-37007; human REDD1, #sc-45806; mouse Redd1, #sc-45807; human IKKβ, #sc-35644; human NF-κB p65, #sc-29410; mouse NF-κB p65, #sc- 29411; human Raptor, #44069; human DICER, #sc40489; Santa Cruz Biotechnology), miRNA mimics or inhibitors (80 nM, Supplementary Table 1), pFLAG-REDD1 (1 μg DNA/ml)19, or plasmid DNAs (1 μg/ml; human WT or DN mutant H363Y SIRT1; Plasmid #1791, Addgene, Watertown, MA, USA) using Lipofectamine RNAiMAX or Lipofectamine 3000 (Invitrogen). .. Cells were then treated with or without oxLDL (50 μg/ml), prepared by incubating native LDL (1.019 mg protein) with 10 μM CuSO4 for 4 h64, cholesterol (100 μM, #C8667; Sigma-Aldrich, St. Louis, MO, USA), glucose (25 mM, 25 mM L-glucose used for osmotic control), recombinant human resistin (100 ng/ml, #1359-RN; R&D systems, Minneapolis, MN, USA), recombinant human leptin (10 μg/ml, #398-LP; R&D Systems), recombinant human TNF-α (10 ng/ml, #10291-TA; R&D Systems), recombinant human IL-6 (40 ng/ml, #206-IL; R&D Systems), palmitate-BSA (300 μM), or H2O2 (50−150 μM) for 48 h. Palmitic acid-BSA solution (5 mM) was prepared by mixing 10 μL of palmitate solution (500 mM in ethanol, #P9767; Sigma-Aldrich) with 1 mL of BSA solution (10%, w/v in serum-free M199, #A8806; Sigma-Aldrich). ..

    Article Title: Ethyl acetate fraction of Curcuma longa leaves suppresses IL-6-induced STAT3 activation via ERK signaling in Hep3B cells.
    Article Snippet: .. Recombinant human IL‐6 was procured from R&D Systems. .. Mouse anti‐phospho STAT3 (Tyr705) IgG was obtained from Calbiochem.

    Article Title: Inhibition of long-lived plasma cells, a critical role for Telitacicept treatment to systemic lupus erythematosus.
    Article Snippet: Background: Telitacicept (RC18, RemeGen, Ltd) is a novel human TACI-Fc fusion protein that combines B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL).. RC18 has recently been approved in China for the treatment of systemic lupus erythematosus (SLE), demonstrating its safety and efficacy in the majority of the target population.. However, the unique pharmacological mechanism of RC18 has not yet been fully elucidated.

    Article Title: IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non-small cell lung cancer.
    Article Snippet: Infliximab (Mitsubishi Tanabe Pharma, Osaka, Japan) and tocilizumab (Chugai Pharmaceutical, Tokyo, Japan) were stored at − 20 °C. .. Recombinant human TNF-α (#210-TA-005, R&D Systems), recombinant human IFN-γ (#300-02, Peprotech), and recombinant human IL-6 (#206-IL, R&D Systems) were dissolved in sterile phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin and were stored at − 20 °C. .. Cells were transferred to 96-well plates (Greiner BioOne) and subjected to transient transfection for 24 h with a small interfering RNA (siRNA) specific for IFITM3 (ID s195035, Thermo Fisher Scientific) or a negative control siRNA (ID 4390843, Thermo Fisher Scientific), each mixed with the RNAiMAX reagent (Thermo Fisher Scientific).

    Neutralization:

    Article Title: Evaluation of anti-drug antibodies against therapeutic monoclonal antibodies and related product in Japanese patients with rheumatoid arthritis and their clinical impact.
    Article Snippet: All serum samples were filtered through a 0.22-m filter tube (Spin-X Centrifuge Tube Filters; Corning, One Riverfront Plaza, NY) before use. .. Recombinant human TNF- (FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) and recombinant human IL-6 (R&D Systems, Minneapolis, MN) were used for reporter gene assays for evaluating neutralization activity. .. Human anti-IFX antibody HCA215, human anti-ADM antibody HCA204, human anti-GLM monoclonal antibody HCA241, human-TCZ monoclonal antibody HCA254, human antiETN monoclonal antibody HCA 277 (Bio-Rad, Hercules, CA), and mouse anti-ETN monoclonal antibody SB-01-112 (Somru BioScience, PEI, Canada) were used as positive controls.

    Activity Assay:

    Article Title: Evaluation of anti-drug antibodies against therapeutic monoclonal antibodies and related product in Japanese patients with rheumatoid arthritis and their clinical impact.
    Article Snippet: All serum samples were filtered through a 0.22-m filter tube (Spin-X Centrifuge Tube Filters; Corning, One Riverfront Plaza, NY) before use. .. Recombinant human TNF- (FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) and recombinant human IL-6 (R&D Systems, Minneapolis, MN) were used for reporter gene assays for evaluating neutralization activity. .. Human anti-IFX antibody HCA215, human anti-ADM antibody HCA204, human anti-GLM monoclonal antibody HCA241, human-TCZ monoclonal antibody HCA254, human antiETN monoclonal antibody HCA 277 (Bio-Rad, Hercules, CA), and mouse anti-ETN monoclonal antibody SB-01-112 (Somru BioScience, PEI, Canada) were used as positive controls.

    Sterility:

    Article Title: IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR -mutant non–small cell lung cancer
    Article Snippet: Infliximab (Mitsubishi Tanabe Pharma, Osaka, Japan) and tocilizumab (Chugai Pharmaceutical, Tokyo, Japan) were stored at − 20 °C. .. Recombinant human TNF-α (#210-TA-005, R&D Systems), recombinant human IFN-γ (#300-02, Peprotech), and recombinant human IL-6 (#206-IL, R&D Systems) were dissolved in sterile phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin and were stored at − 20 °C. .. Cells were transferred to 96-well plates (Greiner Bio-One) and subjected to transient transfection for 24 h with a small interfering RNA (siRNA) specific for IFITM3 (ID s195035, Thermo Fisher Scientific) or a negative control siRNA (ID 4390843, Thermo Fisher Scientific), each mixed with the RNAiMAX reagent (Thermo Fisher Scientific).

    Article Title: IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non-small cell lung cancer.
    Article Snippet: Infliximab (Mitsubishi Tanabe Pharma, Osaka, Japan) and tocilizumab (Chugai Pharmaceutical, Tokyo, Japan) were stored at − 20 °C. .. Recombinant human TNF-α (#210-TA-005, R&D Systems), recombinant human IFN-γ (#300-02, Peprotech), and recombinant human IL-6 (#206-IL, R&D Systems) were dissolved in sterile phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin and were stored at − 20 °C. .. Cells were transferred to 96-well plates (Greiner BioOne) and subjected to transient transfection for 24 h with a small interfering RNA (siRNA) specific for IFITM3 (ID s195035, Thermo Fisher Scientific) or a negative control siRNA (ID 4390843, Thermo Fisher Scientific), each mixed with the RNAiMAX reagent (Thermo Fisher Scientific).

    Saline:

    Article Title: IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR -mutant non–small cell lung cancer
    Article Snippet: Infliximab (Mitsubishi Tanabe Pharma, Osaka, Japan) and tocilizumab (Chugai Pharmaceutical, Tokyo, Japan) were stored at − 20 °C. .. Recombinant human TNF-α (#210-TA-005, R&D Systems), recombinant human IFN-γ (#300-02, Peprotech), and recombinant human IL-6 (#206-IL, R&D Systems) were dissolved in sterile phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin and were stored at − 20 °C. .. Cells were transferred to 96-well plates (Greiner Bio-One) and subjected to transient transfection for 24 h with a small interfering RNA (siRNA) specific for IFITM3 (ID s195035, Thermo Fisher Scientific) or a negative control siRNA (ID 4390843, Thermo Fisher Scientific), each mixed with the RNAiMAX reagent (Thermo Fisher Scientific).

    Article Title: IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non-small cell lung cancer.
    Article Snippet: Infliximab (Mitsubishi Tanabe Pharma, Osaka, Japan) and tocilizumab (Chugai Pharmaceutical, Tokyo, Japan) were stored at − 20 °C. .. Recombinant human TNF-α (#210-TA-005, R&D Systems), recombinant human IFN-γ (#300-02, Peprotech), and recombinant human IL-6 (#206-IL, R&D Systems) were dissolved in sterile phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin and were stored at − 20 °C. .. Cells were transferred to 96-well plates (Greiner BioOne) and subjected to transient transfection for 24 h with a small interfering RNA (siRNA) specific for IFITM3 (ID s195035, Thermo Fisher Scientific) or a negative control siRNA (ID 4390843, Thermo Fisher Scientific), each mixed with the RNAiMAX reagent (Thermo Fisher Scientific).

    Modification:

    Article Title: Inhibition of long-lived plasma cells, a critical role for Telitacicept treatment to systemic lupus erythematosus.
    Article Snippet: Background: Telitacicept (RC18, RemeGen, Ltd) is a novel human TACI-Fc fusion protein that combines B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL).. RC18 has recently been approved in China for the treatment of systemic lupus erythematosus (SLE), demonstrating its safety and efficacy in the majority of the target population.. However, the unique pharmacological mechanism of RC18 has not yet been fully elucidated.



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    Journal: Scientific Reports

    Article Title: Loganin alleviates oxidative stress-induced apoptosis by modulating mitochondrial function and STAT3 signaling in DSS-induced colitis and H 2 O 2 -injured Caco-2 cells

    doi: 10.1038/s41598-026-55447-3

    Figure Lengend Snippet: Network pharmacology and molecular docking analysis of loganin-associated targets in UC. ( A ) Venn diagram showing the overlap between loganin-related targets and UC-associated genes. ( B ) Protein-protein interaction (PPI) network of the overlapping targets, highlighting key hub genes involved in loganin’s potential mechanisms, including TNF, EGFR, IL6, STAT3, and BCL2. ( C ) Molecular docking of loganin with IL-6. ( D ) Molecular docking of loganin with STAT3.

    Article Snippet: To establish the oxidative stress model, Caco-2 cells were exposed to H 2 O 2 (100 μM) for 12 h. For interleukin-6 (IL-6) supplementation experiments, recombinant human IL-6 (MedChemExpress, HY-P7044) was added at 10 ng/mL for 24 h in the H 2 O 2 + loganin group before subsequent analyses, with reference to previous studies using IL-6 stimulation in Caco-2 cells .

    Techniques:

    Loganin inhibits apoptosis through the IL-6/STAT3/BCL2 signaling pathway in H 2 O 2 -induced epithelial cell injury. ( A ) Western blot analysis of apoptosis-related proteins Bcl-2, BAX, pro-caspase-3, and cleaved caspase-3. ( B – D ) Quantification of BAX, Bcl-2, and cleaved caspase-3 protein levels. ( E ) Western blot analysis of STAT3 and p-STAT3 protein levels. ( F ) Quantification of p-STAT3 protein levels. ( G ) Flow cytometry analysis of apoptosis in Ctrl, H 2 O 2 , H 2 O 2 + loganin, and H 2 O 2 + loganin + IL-6 groups. ( H ) Quantification of apoptosis rate. ( I ) Western blot analysis of apoptosis-related proteins Bcl-2, BAX, pro-caspase-3, and cleaved caspase-3 in Ctrl, H 2 O 2 , H 2 O 2 + loganin, and H 2 O 2 + loganin + IL-6 groups. ( J – L ) Quantification of BAX, Bcl-2, and cleaved caspase-3 protein levels, respectively. ( M ) Western blot analysis of STAT3 and p-STAT3 protein levels. ( N ) Quantification of p-STAT3 protein levels. Data are presented as mean ± SD ( n = 4 per group). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001; ns, not significant. For panels A–F, H 2 O 2 was compared with Ctrl, H 2 O 2 + loganin was compared with H 2 O 2 , and the loganin group was compared with Ctrl. For panels G–N, H 2 O 2 was compared with Ctrl, H 2 O 2 + loganin was compared with H 2 O 2 , and H 2 O 2 + loganin + IL-6 was compared with H 2 O 2 + loganin.

    Journal: Scientific Reports

    Article Title: Loganin alleviates oxidative stress-induced apoptosis by modulating mitochondrial function and STAT3 signaling in DSS-induced colitis and H 2 O 2 -injured Caco-2 cells

    doi: 10.1038/s41598-026-55447-3

    Figure Lengend Snippet: Loganin inhibits apoptosis through the IL-6/STAT3/BCL2 signaling pathway in H 2 O 2 -induced epithelial cell injury. ( A ) Western blot analysis of apoptosis-related proteins Bcl-2, BAX, pro-caspase-3, and cleaved caspase-3. ( B – D ) Quantification of BAX, Bcl-2, and cleaved caspase-3 protein levels. ( E ) Western blot analysis of STAT3 and p-STAT3 protein levels. ( F ) Quantification of p-STAT3 protein levels. ( G ) Flow cytometry analysis of apoptosis in Ctrl, H 2 O 2 , H 2 O 2 + loganin, and H 2 O 2 + loganin + IL-6 groups. ( H ) Quantification of apoptosis rate. ( I ) Western blot analysis of apoptosis-related proteins Bcl-2, BAX, pro-caspase-3, and cleaved caspase-3 in Ctrl, H 2 O 2 , H 2 O 2 + loganin, and H 2 O 2 + loganin + IL-6 groups. ( J – L ) Quantification of BAX, Bcl-2, and cleaved caspase-3 protein levels, respectively. ( M ) Western blot analysis of STAT3 and p-STAT3 protein levels. ( N ) Quantification of p-STAT3 protein levels. Data are presented as mean ± SD ( n = 4 per group). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001; ns, not significant. For panels A–F, H 2 O 2 was compared with Ctrl, H 2 O 2 + loganin was compared with H 2 O 2 , and the loganin group was compared with Ctrl. For panels G–N, H 2 O 2 was compared with Ctrl, H 2 O 2 + loganin was compared with H 2 O 2 , and H 2 O 2 + loganin + IL-6 was compared with H 2 O 2 + loganin.

    Article Snippet: To establish the oxidative stress model, Caco-2 cells were exposed to H 2 O 2 (100 μM) for 12 h. For interleukin-6 (IL-6) supplementation experiments, recombinant human IL-6 (MedChemExpress, HY-P7044) was added at 10 ng/mL for 24 h in the H 2 O 2 + loganin group before subsequent analyses, with reference to previous studies using IL-6 stimulation in Caco-2 cells .

    Techniques: Western Blot, Flow Cytometry